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Primary Research Articles (Selected)

2021

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain and emotional valence. C.H. Chen, L.N. Newman,  A.P. Stark, K. E. Bond, D. Zhang, K. Mutume,  I. Flaquer,  W.G. Regehr. bioRxiv 2021.09.21.461236. [pdf].

Weyrer, C., Turecek, J., Harrison, B. & Regehr, W. G. Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse. Cell Rep 36, 109719, doi:10.1016/j.celrep.2021.109719 (2021). [pdf].

Hull, C and Regehr, WG. The cerebellar cortex. 2021. [submitted]. Please email authors with comments and suggestions for this review article.

Osorno T, Rudolph S, Nguyen T, Kozareva V, Nadaf N, Macosko EZ, Lee W-C A, Regehr WG. Candelabrum cells are molecularly distinct, ubiquitous interneurons of the cerebellar cortex with specialized circuit properties, 2021. [BioRxiv]

Wang C-C, Weyrer C, Fioravante D, Kaeser PS, Regehr WG. Short-term plasticity persists in the absence of PKC phosphorylation of Munc18-1. J. Neurosci. 2021 41(35) 7329-7339. [pdf]

Guo C, RudoGuo, C., Rudolph, S., Neuwirth, M. E. & Regehr, W. G. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. Elife 10, doi:10.7554/eLife.68802 (2021). [pdf]

Guo C, Huson V, Macosko EZ, and Regehr WG, Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells. Nature Communications. 2021. [pdf]

Kozareva, V et al., Regehr WG and Macosko EZ, A transcriptomic atlas of the mouse cerebellum reveals regional specializations and novel cell types. Nature. 2021. [pdf]

2020

Turecek, J. and W.G. Regehr, Synaptic inputs to the inferior olive from cerebellar and vestibular nuclei have distinct release kinetics and neurotransmitters. 2020. [pdf]

Han, K.-S., et al., Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling. Nature Neuroscience, 2020. [pdf].

Khan, M.M. and W.G. Regehr, Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions. elife, 2020. 9. [eLife]

Jackman, S.L., et al and W.G. Regehr, Cerebellar Purkinje cell activity modulates aggressive behavior. elife, 2020. 9. [eLife]

Huson, V. and W.G. Regehr, Diverse roles of Synaptotagmin-7 in regulating vesicle fusion. Curr Opin Neurobiol, 2020. 63: p. 42-52. [pdf]

Rudolph, S., et al., Cerebellum-specific deletion of the GABAA receptor δ subunit leads to sex-specific disruption of behavior. Cell Reports, 2020. 33, 108338 [pdf]

2019

Weyrer, C., et al., The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep, 2019. 26(9): p. 2289-2297 e3. [pdf]

Turecek, J. and W.G. Regehr, Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release. Neuron, 2019. 101(5): p. 938-949 e4. [pdf]

Jackman, S.L., C.H. Chen, and W.G. Regehr, In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films. J Vis Exp, 2019(144).

2018

Turecek, J. and W.G. Regehr, Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses. J Neurosci, 2018. 38(13): p. 3240-3251. [pdf]

Tsai, P.T., et al., Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors. Cell Rep, 2018. 25(2): p. 357-367 e4. [Cell Reports]

Jackman, S.L., et al., Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep, 2018. 22(12): p. 3351-3361. [pdf]

Han, K.S., et al., Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells. Neuron, 2018. 100(3): p. 564-578 e3. [pdf]

2017

Turecek, J., S.L. Jackman, and W.G. Regehr, Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses. Nature, 2017. 551(7681): p. 503-506. [pdf]

Kaeser, P.S. and W.G. Regehr, The readily releasable pool of synaptic vesicles. Curr Opin Neurobiol, 2017. 43: p. 63-70. [pdf]

Jackman, S.L. and W.G. Regehr, The Mechanisms and Functions of Synaptic Facilitation. Neuron, 2017. 94(3): p. 447-464. [pdf]

2016

Witter, L., et al., Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons. Neuron, 2016. 91(2): p. 312-9. [pdf]

Wang, C.C., et al., Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse. J Neurosci, 2016. 36(24): p. 6393-402. [pdf]

Turecek, J., S.L. Jackman, and W.G. Regehr, Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex. Cell Rep, 2016. 17(12): p. 3256-3268. [pdf]

Thanawala, M.S. and W.G. Regehr, Determining synaptic parameters using high-frequency activation. J Neurosci Methods, 2016. 264: p. 136-152. [pdf]

Jackman, S.L., et al., The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature, 2016. 529(7584): p. 88-91. [pdf]

Guo, C., et al., Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex. Neuron, 2016. 91(6): p. 1330-1341. [pdf]

2015

Tang, J.C., et al., Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci, 2015. 18(9): p. 1334-41. [pdf]

Rudolph, S., C. Hull, and W.G. Regehr, Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells. J Neurosci, 2015. 35(47): p. 15492-504. [pdf]

2014

Liu, A. and W.G. Regehr, Normalization of input patterns in an associative network. J Neurophysiol, 2014. 111(3): p. 544-51. [pdf]

Kaeser, P.S. and W.G. Regehr, Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol, 2014. 76: p. 333-63. [pdf]

Jackman, S.L., et al., Achieving high-frequency optical control of synaptic transmission. J Neurosci, 2014. 34(22): p. 7704-14. [pdf]

Chu, Y., et al., Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity. Neuron, 2014. 82(4): p. 859-71. [pdf]

Brenowitz, S.D. and W.G. Regehr, Presynaptic calcium measurements using bulk loading of acetoxymethyl indicators. Cold Spring Harb Protoc, 2014. 2014(7): p. 750-7. [pdf]

Antal, M., B.M. Beneduce, and W.G. Regehr, The substantia nigra conveys target-dependent excitatory and inhibitory outputs from the basal ganglia to the thalamus. J Neurosci, 2014. 34(23): p. 8032-42. [pdf]

2013

Thanawala, M.S. and W.G. Regehr, Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool. J Neurosci, 2013. 33(11): p. 4625-33. [pdf]

Pressler, R.T. and W.G. Regehr, Metabotropic glutamate receptors drive global persistent inhibition in the visual thalamus. J Neurosci, 2013. 33(6): p. 2494-506. [pdf]

Hull, C.A., et al., Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci, 2013. 33(14): p. 5895-902. [pdf]

2012

Tsai, P.T., et al., Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature, 2012. 488(7413): p. 647-51. [pdf]

Regehr, W.G., Short-term presynaptic plasticity. Cold Spring Harb Perspect Biol, 2012. 4(7): p. a005702. [pdf]

Hull, C. and W.G. Regehr, Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron, 2012. 73(1): p. 149-58. [pdf]

Fioravante, D., et al., Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC. J Neurosci, 2012. 32(38): p. 13004-9. [pdf]

Chu, Y., et al., Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci, 2012. 32(40): p. 13796-804. [pdf]

2011

Myoga, M.H. and W.G. Regehr, Calcium microdomains near R-type calcium channels control the induction of presynaptic long-term potentiation at parallel fiber to purkinje cell synapses. J Neurosci, 2011. 31(14): p. 5235-43. [pdf]

Fioravante, D. and W.G. Regehr, Short-term forms of presynaptic plasticity. Curr Opin Neurobiol, 2011. 21(2): p. 269-74. [pdf]

Fioravante, D., et al., Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron, 2011. 70(5): p. 1005-19.

Carey, M.R., et al., Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses. J Neurophysiol, 2011. 105(2): p. 958-63. [pdf]

2010

Best, A.R. and W.G. Regehr, Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. Neuron, 2010. 65(3): p. 291-2. [pdf]

Antal, M., et al., Cholinergic activation of M2 receptors leads to context-dependent modulation of feedforward inhibition in the visual thalamus. PLoS Biol, 2010. 8(4): p. e1000348. [PLoS Biol]

2009

Regehr, W.G., M.R. Carey, and A.R. Best, Activity-dependent regulation of synapses by retrograde messengers. Neuron, 2009. 63(2): p. 154-70. [pdf]

Myoga, M.H., M. Beierlein, and W.G. Regehr, Somatic spikes regulate dendritic signaling in small neurons in the absence of backpropagating action potentials. J Neurosci, 2009. 29(24): p. 7803-14. [pdf]

Kim, J.C., et al., Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron, 2009. 63(3): p. 305-15. [pdf]

Crowley, J.J., D. Fioravante, and W.G. Regehr, Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. Neuron, 2009. 63(6): p. 843-53. [pdf]

Carey, M.R. and W.G. Regehr, Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals. Neuron, 2009. 62(1): p. 112-22. [pdf]

Best, A.R. and W.G. Regehr, Inhibitory regulation of electrically coupled neurons in the inferior olive is mediated by asynchronous release of GABA. Neuron, 2009. 62(4): p. 555-65. [pdf]

2008

Safo, P. and W.G. Regehr, Timing dependence of the induction of cerebellar LTD. Neuropharmacology, 2008. 54(1): p. 213-8. [pdf]

Best, A.R. and W.G. Regehr, Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses. J Neurosci, 2008. 28(25): p. 6508-15. [pdf]

Acuna-Goycolea, C., S.D. Brenowitz, and W.G. Regehr, Active dendritic conductances dynamically regulate GABA release from thalamic interneurons. Neuron, 2008. 57(3): p. 420-31. [pdf]

2007

Crowley, J.J., A.G. Carter, and W.G. Regehr, Fast vesicle replenishment and rapid recovery from desensitization at a single synaptic release site. J Neurosci, 2007. 27(20): p. 5448-60. [pdf]

Brenowitz, S.D. and W.G. Regehr, Reliability and heterogeneity of calcium signaling at single presynaptic boutons of cerebellar granule cells. J Neurosci, 2007. 27(30): p. 7888-98. [pdf]

Beierlein, M., D. Fioravante, and W.G. Regehr, Differential expression of posttetanic potentiation and retrograde signaling mediate target-dependent short-term synaptic plasticity. Neuron, 2007. 54(6): p. 949-59. [pdf]

2006

Safo, P.K., B.F. Cravatt, and W.G. Regehr, Retrograde endocannabinoid signaling in the cerebellar cortex. Cerebellum, 2006. 5(2): p. 134-45. [pdf]

Brenowitz, S.D., A.R. Best, and W.G. Regehr, Sustained elevation of dendritic calcium evokes widespread endocannabinoid release and suppression of synapses onto cerebellar Purkinje cells. J Neurosci, 2006. 26(25): p. 6841-50. [pdf]

Beierlein, M. and W.G. Regehr, Brief bursts of parallel fiber activity trigger calcium signals in bergmann glia. J Neurosci, 2006. 26(26): p. 6958-67. [pdf]

Beierlein, M. and W.G. Regehr, Local interneurons regulate synaptic strength by retrograde release of endocannabinoids. J Neurosci, 2006. 26(39): p. 9935-43. [pdf]

2005

Xu-Friedman, M.A. and W.G. Regehr, Dynamic-clamp analysis of the effects of convergence on spike timing. I. Many synaptic inputs. J Neurophysiol, 2005. 94(4): p. 2512-25. [pdf]

Xu-Friedman, M.A. and W.G. Regehr, Dynamic-clamp analysis of the effects of convergence on spike timing. II. Few synaptic inputs. J Neurophysiol, 2005. 94(4): p. 2526-34. [pdf]

Safo, P.K. and W.G. Regehr, Endocannabinoids control the induction of cerebellar LTD. Neuron, 2005. 48(4): p. 647-59. [pdf]

Foster, K.A., J.J. Crowley, and W.G. Regehr, The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses. J Neurosci, 2005. 25(50): p. 11655-65. [pdf]

Brenowitz, S.D. and W.G. Regehr, Associative short-term synaptic plasticity mediated by endocannabinoids. Neuron, 2005. 45(3): p. 419-31. [pdf]

Blitz, D.M. and W.G. Regehr, Timing and specificity of feed-forward inhibition within the LGN. Neuron, 2005. 45(6): p. 917-28. [pdf]

2004

Xu-Friedman, M.A. and W.G. Regehr, Structural contributions to short-term synaptic plasticity. Physiol Rev, 2004. 84(1): p. 69-85. [pdf]

Foster, K.A. and W.G. Regehr, Variance-mean analysis in the presence of a rapid antagonist indicates vesicle depletion underlies depression at the climbing fiber synapse. Neuron, 2004. 43(1): p. 119-31. [pdf]

Brown, S.P., P.K. Safo, and W.G. Regehr, Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels. J Neurosci, 2004. 24(24): p. 5623-31. [pdf]

Blitz, D.M., K.A. Foster, and W.G. Regehr, Short-term synaptic plasticity: a comparison of two synapses. Nat Rev Neurosci, 2004. 5(8): p. 630-40.

Beierlein, M., et al., Presynaptic calcium measurements at physiological temperatures using a new class of dextran-conjugated indicators. J Neurophysiol, 2004. 92(1): p. 591-9. [pdf]

Abbott, L.F. and W.G. Regehr, Synaptic computation. Nature, 2004. 431(7010): p. 796-803. [pdf]

2003

Xu-Friedman, M.A. and W.G. Regehr, Ultrastructural contributions to desensitization at cerebellar mossy fiber to granule cell synapses. J Neurosci, 2003. 23(6): p. 2182-92. [pdf]

Chen, C. and W.G. Regehr, Presynaptic modulation of the retinogeniculate synapse. J Neurosci, 2003. 23(8): p. 3130-5. [pdf]

Brown, S.P., S.D. Brenowitz, and W.G. Regehr, Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids. Nat Neurosci, 2003. 6(10): p. 1048-57. [pdf]

Brenowitz, S.D. and W.G. Regehr, Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells. J Neurosci, 2003. 23(15): p. 6373-84. [pdf]

Blitz, D.M. and W.G. Regehr, Retinogeniculate synaptic properties controlling spike number and timing in relay neurons. J Neurophysiol, 2003. 90(4): p. 2438-50. [pdf]

2002

Zucker, R.S. and W.G. Regehr, Short-term synaptic plasticity. Annu Rev Physiol, 2002. 64: p. 355-405. [pdf]

Kreitzer, A.C., A.G. Carter, and W.G. Regehr, Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron, 2002. 34(5): p. 787-96. [pdf]

Foster, K.A., A.C. Kreitzer, and W.G. Regehr, Interaction of postsynaptic receptor saturation with presynaptic mechanisms produces a reliable synapse. Neuron, 2002. 36(6): p. 1115-26. [pdf]

Chen, C., D.M. Blitz, and W.G. Regehr, Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse. Neuron, 2002. 33(5): p. 779-88. [pdf]

Carter, A.G., et al., Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. J Neurosci, 2002. 22(1): p. 21-8. [pdf]

Carter, A.G. and W.G. Regehr, Quantal events shape cerebellar interneuron firing. Nat Neurosci, 2002. 5(12): p. 1309-18. [pdf]

2001

Xu-Friedman, M.A., K.M. Harris, and W.G. Regehr, Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neurosci, 2001. 21(17): p. 6666-72. [pdf]

Vogt, K.E. and W.G. Regehr, Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus. J Neurosci, 2001. 21(1): p. 75-83. [pdf]

Kreitzer, A.C. and W.G. Regehr, Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron, 2001. 29(3): p. 717-27. [pdf]

Kreitzer, A.C. and W.G. Regehr, Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J Neurosci, 2001. 21(20): p. RC174. [pdf]

2000

Xu-Friedman, M.A. and W.G. Regehr, Probing fundamental aspects of synaptic transmission with strontium. J Neurosci, 2000. 20(12): p. 4414-22. [pdf]

Kreitzer, A.C. and W.G. Regehr, Modulation of transmission during trains at a cerebellar synapse. J Neurosci, 2000. 20(4): p. 1348-57. [pdf]

Kreitzer, A.C., et al., Monitoring presynaptic calcium dynamics in projection fibers by in vivo loading of a novel calcium indicator. Neuron, 2000. 27(1): p. 25-32. [pdf]

Dittman, J.S., A.C. Kreitzer, and W.G. Regehr, Interplay between facilitation, depression, and residual calcium at three presynaptic terminals. J Neurosci, 2000. 20(4): p. 1374-85. [pdf]

Chen, C. and W.G. Regehr, Developmental remodeling of the retinogeniculate synapse. Neuron, 2000. 28(3): p. 955-66. [pdf]

Carter, A.G. and W.G. Regehr, Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse. J Neurosci, 2000. 20(12): p. 4423-34. [pdf]

1999

Xu-Friedman, M.A. and W.G. Regehr, Presynaptic strontium dynamics and synaptic transmission. Biophys J, 1999. 76(4): p. 2029-42. [pdf]

Sabatini, B.L. and W.G. Regehr, Timing of synaptic transmission. Annu Rev Physiol, 1999. 61: p. 521-42.

Chen, C. and W.G. Regehr, Contributions of residual calcium to fast synaptic transmission. J Neurosci, 1999. 19(15): p. 6257-66. [pdf]

1998

Sabatini, B.L. and W.G. Regehr, Optical measurement of presynaptic calcium currents. Biophys J, 1998. 74(3): p. 1549-63. [pdf]

Dittman, J.S. and W.G. Regehr, Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse. J Neurosci, 1998. 18(16): p. 6147-62. [pdf]

Atluri, P.P. and W.G. Regehr, Delayed release of neurotransmitter from cerebellar granule cells. J Neurosci, 1998. 18(20): p. 8214-27. [pdf]

1997

Sabatini, B.L. and W.G. Regehr, Control of neurotransmitter release by presynaptic waveform at the granule cell to Purkinje cell synapse. J Neurosci, 1997. 17(10): p. 3425-35. [pdf]

Regehr, W.G., Interplay between sodium and calcium dynamics in granule cell presynaptic terminals. Biophys J, 1997. 73(5): p. 2476-88. [pdf]

Dittman, J.S. and W.G. Regehr, Mechanism and kinetics of heterosynaptic depression at a cerebellar synapse. J Neurosci, 1997. 17(23): p. 9048-59. [pdf]

Chen, C. and W.G. Regehr, The mechanism of cAMP-mediated enhancement at a cerebellar synapse. J Neurosci, 1997. 17(22): p. 8687-94. [pdf]

1996

Sabatini, B.L. and W.G. Regehr, Timing of neurotransmission at fast synapses in the mammalian brain. Nature, 1996. 384(6605): p. 170-2. [pdf]

Dittman, J.S. and W.G. Regehr, Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse. J Neurosci, 1996. 16(5): p. 1623-33. [pdf]

Atluri, P.P. and W.G. Regehr, Determinants of the time course of facilitation at the granule cell to Purkinje cell synapse. J Neurosci, 1996. 16(18): p. 5661-71. [pdf]

1995

Tank, D.W., W.G. Regehr, and K.R. Delaney, A quantitative analysis of presynaptic calcium dynamics that contribute to short-term enhancement. J Neurosci, 1995. 15(12): p. 7940-52.

Sabatini, B.L. and W.G. Regehr, Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice. Neuropharmacology, 1995. 34(11): p. 1453-67.

Regehr, W.G. and P.P. Atluri, Calcium transients in cerebellar granule cell presynaptic terminals. Biophys J, 1995. 68(5): p. 2156-70.

Mintz, I.M., B.L. Sabatini, and W.G. Regehr, Calcium control of transmitter release at a cerebellar synapse. Neuron, 1995. 15(3): p. 675-88. [pdf]

1994

Regehr, W.G. and D.W. Tank, Dendritic calcium dynamics. Curr Opin Neurobiol, 1994. 4(3): p. 373-82.

Regehr, W.G. and I.M. Mintz, Participation of multiple calcium channel types in transmission at single climbing fiber to Purkinje cell synapses. Neuron, 1994. 12(3): p. 605-13.

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