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We are interested in recruiting students and postdoctoral fellows with backgrounds and interests in neurobiology, cell and molecular biology, systems biology, imaging, computational biology, biophysics, physics and engineering. Recent papers give insight into the types of projects that are available.

The lab studies diverse topics ranging from the control of neurotransmitter release to the behavioral roles of the cerebellum.  Synaptic plasticity has been a long-standing interest of the lab. In recent years we have focused on the molecular control of release kinetics and short-term synaptic plasticity, and the functional and behavioral roles of these synaptic properties.  We also study many aspects of the cerebellum.  The prevailing view has been that the cerebellum is comprised of a relatively simple circuit involved in motor function and motor learning.  It is increasingly apparent, however, that the cerebellar circuit and behavioral roles of the cerebellum are much more complex than previously appreciated.  It is an exciting time to study the cerebellum. Recent studies indicate that there are additional circuit elements, connections, and types of signaling within the cerebellum.  It has also become clear that the cerebellum also regulates diverse social behaviors.  Our studies clarify circuits, and provide insights into how the cerebellum controls various behaviors, and how cerebellar disfunction leads to neurological disorders such as autism

Major Questions:
• What are the mechanisms that control the kinetics of neurotransmitter release?
• What are the mechanisms of short-term synaptic plasticity?
• What are the functional and behavioral contributions of short-term synaptic plasticity?
• What are the circuit elements and the connectivity within the cerebellar cortex, and how are they specialized to serve different functional roles?
• What behaviors are controlled by the cerebellum?

Techniques:
• Slice electrophysiology, calcium measurements and caged neurotransmitters.
• Mouse genetics, optogenetics and AAV manipulations.
• Immunofluorescence, FISH and serial electron reconstructions (with the Lee lab).
• Behavioral analysis (many social behaviors, gait analysis, Motion Seq, VOR, conditioned eyeblink, etc.)
• Single cell molecular analysis (with the Macosko lab) and functional characterization of cerebellar neurons.
• 2-photon functional imaging (with the Harvey lab) and single unit electrophysiology in behaving animals

UNDERGRADUATE STUDENTS
Students are welcome to apply to the Regehr lab to gain research experience and to perform senior theses. Students are encouraged to apply early in their college careers. The Regehr lab is housed on the Longwood Campus of the Harvard Medical School. Transportation to the Longwood Medical Area is very convenient. There is an M2 shuttle from Harvard Square to MIT to Longwood that is free for all Harvard and MIT students.

GRADUATE STUDENTS
The Regehr lab can accept graduate students from any of the graduate programs at Harvard University including the Program in Neuroscience, BBS, Biophysics or Molecular and Cellular Biology via the Harvard Integrated Life Sciences program (HILS). The Regehr lab is directly affiliated with the Harvard Program in Neuroscience, and the Harvard M.D./Ph.D. program. Many graduate students and MD/PhD students have received their training and PhD in the Regehr lab. The vast majority have finished in a timely manner, published multiple papers in high quality journals, and have gone on to do postdocs in strong labs. Many former trainees are now PIs. Students interested in rotating in the Regehr lab should email wade_regehr@hms.harvard.edu.

POSTDOCTORAL FELLOWS
The Regehr lab is seeking postdoctoral fellows to work in an interactive lab environment in which the candidate will use multiple cutting edge techniques to address diverse questions.  The ideal candidate should be creative, able to both lead their own independent project, and able to work with others on collaborative projects in a highly interactive environment. Please email a cover letter, a curriculum vitae, and names & email addresses of three references to wade_regehr@hms.harvard.edu

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